{"id":24860,"date":"2023-09-05T08:55:37","date_gmt":"2023-09-05T13:55:37","guid":{"rendered":"https:\/\/www.aae.org\/specialty\/?p=24860"},"modified":"2023-09-05T14:53:01","modified_gmt":"2023-09-05T19:53:01","slug":"catching-up-with-canada-research-chair-tier-1-professor-anil-kishen","status":"publish","type":"post","link":"https:\/\/www.aae.org\/specialty\/catching-up-with-canada-research-chair-tier-1-professor-anil-kishen\/","title":{"rendered":"Catching Up With Canada Research Chair Tier 1 Professor Anil Kishen"},"content":{"rendered":"

\"\"By Elisabeth Lisican
\n<\/em>
\nThe future of endodontics might be nano — but the benefits could be larger than life.<\/p>\n

As announced in the August Communiqu\u00e9<\/em>, AAE member; Journal of Endodontics <\/em>Associate Editor; and University of Toronto Faculty of Dentistry Associate Dean, Graduate Education, and Professor Anil Kishen has received Canada Research Chair Tier 1 designation and funding for his work in oral health nanomedicine.<\/p>\n

Combining his background in clinical sciences (dentistry and endodontics) and biomedical engineering, Professor Kishen has led the Kishen Lab for the past two decades. The Kishen Lab has been working with nanoparticles since 2005 and is credited with developing many innovations over the years. For example, they developed a special varnish for orthodontic patients that was a natural alternative to fluoride. They\u2019ve also developed a novel new product for tooth sensitivity that offers temporary relief immediately.<\/p>\n

\u201cThe beauty of this is it is all done by using bioactive natural material,\u201d Dr. Kishen said. \u201cWe can tune the physical and chemical properties of this material at the nano level, and we can achieve different kinds of benefits.\u201d<\/p>\n

For each Tier 1 Chair, the institution receives $200,000 annually for seven years. But the title of Research Chair Tier 1 entails more than the securing of funding — it is a position granted, identifying an individual as someone who is doing research of excellence.<\/p>\n

The Canada Research Chairs Program invests up to $311 million per year to attract and retain some of the world\u2019s most accomplished and promising minds. Chairholders aim to achieve research excellence in engineering and the natural sciences, health sciences, humanities, and social sciences.<\/p>\n

\u201cIt\u2019s a real honor for me,\u201d Dr. Kishen said.<\/p>\n

Over the next seven years, Dr. Kishen\u2019s lab will be using multifunctional bioactive nanoparticles to examine wound healing and cellular crosstalk mechanisms.<\/p>\n

Nanoparticles are materials with overall dimensions in the nanoscale — under 100 nm — that play a key role in nanomedicine. The Kishen Lab works with chitosan-based nanoparticles. Scientists process chitosan powder into nanoparticles that are then optimized through modification of their physical properties, molecular structure, and more. Nanoparticles are optimized differently for each therapeutic application.<\/p>\n

So far, the Kishen Lab has demonstrated how engineered chitosan-based nanoparticles support healing in patients with different oral health issues, including apical periodontitis and inflammatory root resorption. His paper Maxillary Anterior Teeth With Extensive Root Resorption Treated With Low-level Light-activated Engineered Chitosan Nanoparticles<\/a> earned him a JOE <\/em>Award in 2022.<\/p>\n

In a study on apical periodontitis, Dr. Kishen used engineered nanoparticles to influence the patients\u2019 own natural healing response to allow the patients\u2019 previously inflamed tissue to heal rapidly. He demonstrated how engineered chitosan nanoparticles mediated cellular crosstalk in their healing process. In 2021, these investigations were published in the Journal of Endodontics<\/em> as well as the Bioactive Materials Journal<\/em>.<\/a><\/p>\n

Dr. Kishen also sees potential for many other therapeutic applications. His lab will be exploring utilizing nanoparticles as part of a therapeutic strategy for saving infected natural teeth. Outside of dentistry, the Kishen Lab is on the verge of applying their findings for possible treatment of diabetic wounds and ulcers as well as for medication-related osteonecrosis by topically modulating host immune response.<\/p>\n

Thanks to the Canada Research Chair funding, they will examine how cells crosstalk in the presence of bacteria, and how to stimulate that crosstalk to influence healing. To achieve this, Dr. Kishen\u2019s team will be developing three-dimensional tissue and wound models to study the crosstalk mechanism. They will also explore optimizing and functionalizing nanoparticles to make them intelligent.<\/p>\n

The Greater Good<\/strong><\/p>\n

Although working with nanoparticles may urge one to \u201cthink small\u201d, Dr. Kishen\u2019s eyes have always been on the larger implications of what he does.<\/p>\n

\u201cWhen I was a teenager, my dad asked me, \u2018what do you want for your birthday?\u2019 I said, \u2018I think I want a doctor\u2019s kit\u2019 — the plastic stethoscopes and the small needles \u2026 the thermometer \u2026 My dad said, \u2018why do you want to become a doctor?\u2019 I said, \u2018I want to become a doctor because I can treat all the patients; I can heal them all. And I can be a good person.\u2019<\/p>\n

\u201cBut then my dad said, \u2018why don\u2019t you become a scientist? If you become a scientist and you invent something that all the doctors in the world can use \u2026 then you are benefitting all <\/em>the patients.\u2019<\/p>\n

\u201cSo I thought, that\u2019s an interesting idea.\u201d<\/p>\n

That stayed with Dr. Kishen all throughout his professional career and is what helps to keep him motivated each day.<\/p>\n

\u201cIf you have the ability to solve clinical problems which can benefit our patients and you are making some kind of improvement in that, what else would you want to do? You are developing something that can benefit patients \u2013 that is the best part.\u201d<\/p>\n

2023 has proven to be a banner year for Dr. Kishen, who was also appointed as Associate Dean, Graduate Education, at the University of Toronto Faculty of Dentistry, effective on July 1, 2023.<\/p>\n

In his spare time, Dr. Kishen enjoys going on long hikes with his family in the Toronto area.<\/p>\n

In his younger days, Dr. Kishen played sports; these days, he loves to watch sports, including the NBA as well as MLB.<\/p>\n

\u201cNaturally, I support Canadian and Toronto teams. For basketball, we have the Toronto Raptors. I watch games, and I follow India cricket too \u2026 Sports are something I do.\u201d<\/p>\n

All Things Tunable<\/strong><\/p>\n

Dr. Kishen has recently picked up a new hobby — learning the guitar — but says he prefers to keep that on the downlow.<\/p>\n

While you may not get to see him perform music live, you\u2019ll undoubtedly see him continue to make headlines for tuning nanoparticles.<\/p>\n

\u201cI can tune these kinds of particles to promote wound healing,\u201d he said. \u201cI can tune this particle to make it antibacterial\u2026 or, to be like a varnish. These are tunable<\/em> biomaterials. The beauty is it is very cost-effective. You get a lot of benefit at a low cost.\u201d<\/p>\n

Further Reading:<\/strong><\/p>\n

Spring 2023 Recipients (cycle 2022-1) (chairs-chaires.gc.ca)<\/a><\/p>\n

Periodontal Fibroblasts-Macrophage Crosstalk in External Inflammatory Root Resorption.<\/a>
\nRajeshwari HRS,\u00a0Kishen A.<\/strong>J Endod. 2023 Jun 1:S0099-2399(23)00287-X. doi: 10.1016\/j.joen.2023.05.016.<\/p>\n

Deciphering Stem Cell From Apical Papilla-Macrophage Choreography Using a Novel 3-dimensional Organoid System.<\/a>
\nLi FC, Hussein H, Magalhaes M, Selvaganapathy PR,\u00a0Kishen A.<\/strong>J Endod. 2022 Aug;48(8):1063-1072.e7.<\/p>\n

Proteomic profiling reveals engineered chitosan nanoparticles mediated cellular crosstalk and immunomodulation for therapeutic application in apical periodontitis.<\/a>
\nHussein H,\u00a0<\/span>Kishen A.<\/strong>Bioact Mater. 2021 Oct 9;11:77-89
\n<\/span>
\nAssessing Macrophage Polarization in Nanoparticle-Guided Wound Repair Using a Lipopolysaccharide Contaminated Intraosseous Model.<\/a>
\nSingh K, Ali A, Shrestha A, Magalhaes M,\u00a0Kishen A.<\/strong>J Endod. 2022 Jan;48(1):109-116.<\/p>\n

Engineered Chitosan-based Nanoparticles Modulate Macrophage-Periodontal Ligament Fibroblast Interactions in Biofilm-mediated Inflammation.<\/a>
\nHussein H,\u00a0Kishen A.<\/strong>J Endod. 2021 Sep;47(9):1435-1444.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

By Elisabeth Lisican The future of endodontics might be nano — but the benefits could be larger than life. 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