RegEndo: ‘Evidenced-Based Pulp Fiction’ – Ep. 08
We sit down with pulp cell biology expert Dr. George Huang for the engaging story of his early work on dental stem cells, when he began establishing a reputation as a leader — moreover a pioneer — in the new field of “regenerative endodontics”.
His team was the first to show that dental stem cells can be used to regenerate dental pulp and dentin in an emptied root canal space in vivo, and to show that dental stem cells can be easily reprogrammed into induced pluripotent stem cells.
We also investigate the molecular biology of dental stem cells in the context of their applications for pulp regeneration. After nerding out on stem cells, a brief discussion follows on some highly cited review papers.
This conversation ends on a controversial note as we seek to answer: where will technology take stem cell-based pulp regeneration in humans?! Tune in for a glimpse of what the future of endodontics will (re)generate.
Episodes of Endo Voices may include opinion, speculation and other statements not verifiable in the scientific method and do not necessarily reflect the views of AAE or the sponsor(s). Listeners should use their best judgment in evaluating the merits of any content.
- Huang, GTJ, Garcia-Godoy, F. What is Missing for Stem Cell-Based Therapies in Dentistry. J Tenn Dent Assoc, 96 (2), 9-12, 2018.
- Lin, LM, Ricucci, D, Huang, GT. Regeneration of the dentine-pulp complex with revitalization/revascularization therapy: challenges and hopes. Int Endod J, 47 (8), 713-24, 2014.
- Huang, GT, Garcia-Godoy, F. Missing Concepts in De Novo Pulp Regeneration. J Dent Res, 93 (8), 717-724, 2014.