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Building Blocks of RegEndo – Ep. 64

Guest: Avina Paranjpe, B.D.S., M.S., M.S.D., Ph.D.

In this episode of Endo Voices, we engage with Dr. Avina Paranjpe, the distinguished Director of the Endodontic Program at Washington and President of the American Board of Endodontics. This scholarly discussion is an exploration of regenerative endodontics, a.k.a. “regendo”, highlighting its transformative impact on traditional root canal treatments. Dr. Paranjpe provides a thorough analysis of the advancements in techniques, offering a comparative examination with conventional methods and underscoring the potential of contemporary approaches in addressing cases of teeth with open apices. 

She delves into the critical components of regenerative endodontics, including the significance of meticulous disinfection protocols, the role of scaffolds, and the application of stem cells in achieving optimal outcomes. There is an overview of the state-of-the-art protocols and materials highlighting current research, practical applications, and emerging trends within the field. This is an essential resource for endodontic professionals, scholars, and anyone interested in the future trajectory of dental care advancements. 

Episodes of Endo Voices may include opinion, speculation and other statements not verifiable in the scientific method and do not necessarily reflect the views of AAE or the sponsor(s). Listeners should use their best judgment in evaluating the merits of any content. 

Episode Resources

  1. Paranjpe, A., Smoot, T., Zhang, H., & Johnson, J. D. (2011). Direct contact with mineral trioxide aggregate activates and differentiates human dental pulp cells. Journal of endodontics, 37(12), 1691-1695. 
  2. Yan, H., De Deus, G., Kristoffersen, I. M., Wiig, E., Reseland, J. E., Johnsen, G. F., ... & Haugen, H. J. (2023). Regenerative endodontics by cell homing: a review of recent clinical trials. Journal of Endodontics, 49(1), 4-17. 
  3. Ribeiro, J. S., Münchow, E. A., Bordini, E. A. F., da Rosa, W. L. D. O., & Bottino, M. C. (2020). Antimicrobial therapeutics in regenerative endodontics: a scoping review. Journal of endodontics, 46(9), S115-S127. 
  4. Murray PE. Constructs and scaffolds employed to regenerate dental tissue. Dent Clin North Am 2012;56(3):577-588. 
  5. Almutairi W, Yassen GH, Aminoshariae A, Williams KA, Mickel A. Regenerative Endodontics: A Systematic Analysis of the Failed Cases. J Endod 2019;45(5):567-577. 
  6. Torabinejad M, Nosrat A, Verma P, Udochukwu O. Regenerative Endodontic Treatment or Mineral Trioxide Aggregate Apical Plug in Teeth with Necrotic Pulps and Open Apices: A Systematic Review and Meta-analysis. J Endod 2017;43(11):1806-1820